Beta Amyloid Peptide: Research Paper : Association of dyslipidaemia with Alzheimer's disease in a cohort of postmenopausal women

Association of dyslipidaemia with Alzheimer's disease in a cohort of postmenopausal women

Abstract

Objective: To evaluate the association between dyslipidaemia and Alzheimer's disease (AD) in a cohort of postmenopausal women.

Methods: This retrospective study analysed data from postmenopausal women with early AD (group AD) and a cohort of healthy age- and sex-matched control subjects (group NC) that were considered to be within standard limits according to a neuropsychological assessment between March 2010 and March 2019. The primary endpoints were body mass index and lipid-related laboratory parameters, including leptin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, adiponectin, triglycerides, apolipoprotein A1, apolipoprotein B and apolipoprotein E4, which were evaluated using multivariate binary logistic analysis.

Results: The study enrolled 200 postmenopausal women with early AD (mean ± SD age 69.34 ± 6.25 years) and 180 control subjects (mean ± SD age 67.48 ± 7.42 years). Lower HDL-C and higher LDL-C were risk factors for AD. A multivariate binary logistic regression model demonstrated that lower HDL-C and higher LDL-C were the only variables associated with the development of AD (odds ratio [OR] 21.14, 95% confidence interval [CI] 2.47, 4.13; OR 36.35, 95% CI 1.24, 3.38; respectively).

Conclusion: Both low HDL-C and high LDL-C were associated with the occurrence of AD in a cohort of postmenopausal women.

Keywords: Alzheimer's disease; Dyslipidaemia; association; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; postmenopausal.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/32567449/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.