J Am Chem Soc. 2010 Nov 15. [Epub ahead of print]

Intermolecular Alignment in β(2)-Microglobulin Amyloid Fibrils.

Debelouchina GT, Platt GW, Bayro MJ, Radford SE, Griffin RG.

Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, and Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, U.K.

Abstract

The deposition of amyloid-like fibrils, composed primarily of the 99-residue protein β(2)-microglobulin (β(2)m), is one of the characteristic symptoms of dialysis-related amyloidosis. Fibrils formed in vitro at low pH and low salt concentration share many properties with the disease related fibrils and have been extensively studied by a number of biochemical and biophysical methods. These fibrils contain a significant β-sheet core and have a complex cryoEM electron density profile. Here, we investigate the intrasheet arrangement of the fibrils by means of (15)N-(13)C MAS NMR correlation spectroscopy. We utilize a fibril sample grown from a 50:50 mixture of (15)N,(12)C- and (14)N,(13)C-labeled β(2)m monomers, the latter prepared using 2-(13)C glycerol as the carbon source. Together with the use of ZF-TEDOR mixing, this sample allowed us to observe intermolecular (15)N-(13)C backbone-to-backbone contacts with excellent resolution and good sensitivity. The results are consistent with a parallel, in-register arrangement of the protein subunits in the fibrils and suggest that a significant structural reorganization occurs from the native to the fibril state.

PMID: 21077676 [PubMed - as supplied by publisher]

Related citations

 Nephrol Dial Transplant. 2010 Nov 15.

Racial differences in the association of pentraxin-3 with kidney dysfunction: the Multi-Ethnic Study of Atherosclerosis.

Dubin R, Shlipak M, Li Y, Ix J, de Boer IH, Jenny N, Peralta CA.

1Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, CA, USA.

Abstract

BACKGROUND: Pentraxin-3 (PTX3), an inflammatory marker thought to be related to vascular inflammation, is elevated in advanced chronic kidney disease (CKD). Whether PTX3 is associated with mild to moderate kidney dysfunction is unknown.
METHODS: We tested associations of proteins in the pentraxin family [PTX3, C-reactive protein (CRP) and serum amyloid protein (SAP)] with estimated glomerular filtration rate by cystatin C (eGFRcys) and microalbuminuria among 2824 participants in the Multi-Ethnic Study of Atherosclerosis. Associations were tested using multivariable linear regression with adjustment for demographics (age, gender, annual income), comorbidities (diabetes, hypertension, smoking, body mass index, low-density lipoprotein, high-density lipoprotein, triglycerides, ACE inhibitor and statin use) and systemic inflammation [interleukin-6 (IL-6)].
RESULTS: Among the 2824 participants, mean age was 62 years and mean eGFRcys was 94 mL/min/1.73 m(2); 25% were white, 25% Chinese, 25% African-American and 25% Hispanic. Among all participants after full adjustment, higher PTX3 was associated with lower eGFRcys independently of IL-6 (β - 3.0 mL/min/1.73 m(2) per unit increase in lnPTX3, P < 0.001). In contrast, CRP and SAP were associated with eGFRcys in demographic adjusted models, but these associations were attenuated after adjustment for comorbidities and IL-6 (lnCRP β - 0.06, P = 0.9; lnSAP β - 0.35, P = 0.7). There was a significant interaction with race/ethnicity (P < 0.001) in the association of PTX3 and eGFRcys. After adjustment for demographics, comorbidities and IL-6, this association was significant in blacks (β - 5.7 mL/min/1.73 m(2) per unit increase in lnPTX3, P = 0.002) but not in Hispanics (β - 2.4, P = 0.1), Chinese (β - 0.91, P = 0.5) or whites (β - 0.26, P = 0.9). PTX3 and CRP, but not SAP, had correlations with microalbuminuria in unadjusted models (Spearman coefficients PTX3 0.05, P = 0.005; CRP 0.07, P < 0.001; SAP 0.013, P = 0.5), but these were attenuated after full adjustment.
CONCLUSIONS: Endovascular inflammation may be an important mechanism associated with early kidney dysfunction, particularly among blacks. This mechanism appears to be independent of IL-6-regulated pathways.

PMID: 21079193 [PubMed - as supplied by publisher]

Beta Amyloid Peptides ~ Abeta Peptides ~ Amyloid Peptide~Research Papers November 2010

Beta Amyloid Peptides ~ Abeta Peptides ~ Amyloid Peptide~Research Papers November 2010
Chow KM, Guan H, Hersh LB. Aminopeptidases do not directly degrade tau protein. Mol Neurodegener. 2010 Nov 5;5(1):48. PubMed Abstract
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Lange C, Mix E, Frahm J, Glass A, Müller J, Schmitt O, Schmöle AC, Klemm K, Ortinau S, Hübner R, Frech MJ, Wree A, Rolfs A. Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells. Neurosci Lett. 2010 Nov 5; PubMed Abstract
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Park HJ, Bang G, Lee BR, Kim HO, Lee PH. Neuroprotective effect of human mesenchymal stem cells in an animal model of double toxin-induced multiple system atrophy-parkinsonism. Cell Transplant. 2010 Nov 5; PubMed Abstract
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Hatipoglu MG, Kabay SC, Güven G. The clinical evaluation of the oral status in Alzheimer-type dementia patients. Gerodontology. 2010 Nov 5; PubMed Abstract
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Hidalgo C, Carrasco MA. Redox Control of Brain Calcium in Health and Disease. Antioxid Redox Signal. 2010 Nov 5; PubMed Abstract
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Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB, Huryn D. Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies. Curr Top Med Chem. 2010 Nov 4; PubMed Abstract
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Galanakis PA, Bazoti FN, Bergquist J, Markides K, Spyroulias GA, Tsarbopoulos A. Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by NMR spectroscopy. Biopolymers. 2010 Nov 4; PubMed Abstract
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Pascual B, Prieto E, Arbizu J, Marti-Climent J, Olier J, Masdeu JC. Brain Glucose Metabolism in Vascular White Matter Disease With Dementia. Differentiation From Alzheimer Disease. Stroke. 2010 Nov 4; PubMed Abstract
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Rahman A, Brew BJ, Guillemin GJ. Lead Dysregulates Serine/Threonine Protein Phosphatases in Human Neurons. Neurochem Res. 2010 Nov 4; PubMed Abstract
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Cordner Z, Blass DM, Rabins PV, Black BS. Quality of Life in Nursing Home Residents with Advanced Dementia. J Am Geriatr Soc. 2010 Nov 4; PubMed Abstract
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Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han YH, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G. Identification of neuronal RNA targets of TDP-43-containing Ribonucleoprotein complexes. J Biol Chem. 2010 Nov 4; PubMed Abstract
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Khandelwal PJ, Dumanis SB, Feng LR, Maguire-Zeiss K, Rebeck GW, Lashuel HA, E-H Moussa C. Parkinson-related parkin reduces alpha-Synuclein phosphorylation in a gene transfer model. Mol Neurodegener. 2010 Nov 4;5(1):47. PubMed Abstract
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Kaleem A, Hoessli DC, Ul-Haq I, Walker-Nasir E, Butt A, Iqbal Z, Zamani Z, Shakoori AR, Ud-Din N. CREB in long term potentiation in hippocampus: Role of post-translational modifications - studies In silico. J Cell Biochem. 2010 Nov 4; PubMed Abstract
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Sgourakis NG, Merced-Serrano M, Boutsidis C, Drineas P, Du Z, Wang C, Garcia AE. Atomic-level characterization of the ensemble of the Aß(1-42) monomer in water using unbiased Molecular Dynamics simulations and spectral algorithms. J Mol Biol. 2010 Nov 4; PubMed Abstract
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Bohic S, Ghersi-Egea JF, Gibon J, Paoletti P, Arnaud J, Hunot S, Boom A, Bouron A. [Biological roles of trace elements in the brain with special focus on Zn and Fe.] Rev Neurol (Paris). 2010 Nov 4; PubMed Abstract
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McQuiston AR. Mu opioid receptor activation normalizes temporo-ammonic pathway driven inhibition in hippocampal CA1. Neuropharmacology. 2010 Nov 4; PubMed Abstract
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Klöppel C, Michels C, Zimmer J, Herrmann JM, Riemer J. In yeast redistribution of Sod1 to the mitochondrial intermembrane space provides protection against respiration derived oxidative stress. Biochem Biophys Res Commun. 2010 Nov 4; PubMed Abstract
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Ferland CL, Schrader LA. Regulation of histone acetylation in the hippocampus of chronically stressed rats: A potential role of sirtuins. Neuroscience. 2010 Nov 4; PubMed Abstract
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Kim YH, Lussier S, Rane A, Choi SW, Andersen JK. Inducible dopaminergic glutathione depletion in an alpha-synuclein transgenic mouse model results in age-related olfactory dysfunction. Neuroscience. 2010 Nov 3; PubMed Abstract
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Baltanás FC, Casafont I, Weruaga E, Alonso JR, Berciano MT, Lafarga M. Nucleolar disruption and Cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in Purkinje cells. Brain Pathol. 2010 Nov 3; PubMed Abstract
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Small G, Bullock R. Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease. Alzheimers Dement. 2010 Nov 3; PubMed Abstract
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Matsuoka T, Narumoto J, Shibata K, Okamura A, Nakamura K, Nakamae T, Yamada K, Nishimura T, Fukui K. Neural correlates of performance on the different scoring systems of the clock drawing test. Neurosci Lett. 2010 Nov 3; PubMed Abstract
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Li L, Ding J, Marshall C, Gao J, Hu G, Xiao M. Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice. Behav Brain Res. 2010 Nov 3; PubMed Abstract
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Hedskog L, Petersen CA, Svensson AI, Welander H, Tjernberg LO, Karlström H, Ankarcrona M. Gamma-secretase Complexes Containing Caspase-cleaved Presenilin-1 Increase Intracellular Aß42/Aß40 Ratio. J Cell Mol Med. 2010 Nov 3; PubMed Abstract
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Polvikoski TM, van Straaten EC, Barkhof F, Sulkava R, Aronen HJ, Niinistö L, Oinas M, Scheltens P, Erkinjuntti T, Kalaria RN. Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old. Neurology. 2010 Nov 3; PubMed Abstract

Abeta Blog~November 2010~ Beta Amyloid Reserach Papers

Womack KB, Diaz-Arrastia R, Aizenstein HJ, Arnold SE, Barbas NR, Boeve BF, Clark CM, Decarli CS, Jagust WJ, Leverenz JB, Peskind ER, Turner RS, Zamrini EY, Heidebrink JL, Burke JR, Dekosky ST, Farlow MR, Gabel MJ, Higdon R, Kawas CH, Koeppe RA, Lipton AM, Foster NL. Temporoparietal Hypometabolism in Frontotemporal Lobar Degeneration and Associated With Imaging Diagnostic Errors. Arch Neurol. 2010 Nov 8; PubMed Abstract
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Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. {beta}-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J. 2010 Nov 8; PubMed Abstract
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Arvanitakis Z, Leurgans SE, Wang Z, Wilson RS, Bennett DA, Schneider JA. Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Ann Neurol. 2010 Nov 8; PubMed Abstract
 
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Shearer J, Callan PE, Tran T, Szalai VA. Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-ß oligomers compared to amyloid-ß monomers. Chem Commun (Camb). 2010 Nov 8; PubMed Abstract
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Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Mun~oz MJ, Jackson GR, Kayed R. Preparation and Characterization of Neurotoxic Tau Oligomers. Biochemistry. 2010 Nov 8; PubMed Abstract
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Dadon-Nachum M, Melamed E, Offen D. The "Dying-Back" Phenomenon of Motor Neurons in ALS. J Mol Neurosci. 2010 Nov 7; PubMed Abstract
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Mievis S, Blum D, Ledent C. A(2A) receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease. Neurobiol Dis. 2010 Nov 6; PubMed Abstract
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Park HJ, Bang G, Lee BR, Kim HO, Lee PH. Neuroprotective effect of human mesenchymal stem cells in an animal model of double toxin-induced multiple system atrophy-parkinsonism. Cell Transplant. 2010 Nov 5; PubMed Abstract
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van Tijn P, Hobo B, Verhage MC, Oitzl MS, Van Leeuwen FW, Fischer DF. Alzheimer-associated mutant ubiquitin impairs spatial reference memory. Physiol Behav. 2010 Nov 5; PubMed Abstract
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Xing YY, Yu JT, Yan WJ, Chen W, Zhong XL, Jiang H, Wang P, Tan L. NEDD9 is genetically associated with Alzheimer's disease in a Han Chinese population. Brain Res. 2010 Nov 5; PubMed Abstract
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Terry AV, Kutiyanawalla A, Pillai A. Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. Physiol Behav. 2010 Nov 5; PubMed Abstract
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Haupt C, Morgado I, Kumar ST, Parthier C, Bereza M, Hortschansky P, Stubbs MT, Horn U, Fändrich M. Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions. J Mol Biol. 2010 Nov 5; PubMed Abstract
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Motawaj M, Burban A, Davenas E, Arrang JM. ACTIVATION OF BRAIN HISTAMINERGIC NEUROTRANSMISSION: A MECHANISM FOR COGNITIVE EFFECTS OF MEMANTINE IN ALZHEIMER'S DISEASE. J Pharmacol Exp Ther. 2010 Nov 5; PubMed Abstract
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Lewis KA, Su Y, Jou O, Ritchie C, Foong C, Hynan LS, White CL, Thomas PJ, Hatanpaa KJ. Abnormal Neurites Containing C-Terminally Truncated {alpha}-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology. Am J Pathol. 2010 Nov 5; PubMed Abstract
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Sankari Z, Adeli H, Adeli A. Intrahemispheric, interhemispheric, and distal EEG coherence in Alzheimer's disease. Clin Neurophysiol. 2010 Nov 5; PubMed Abstract
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Oliva-Moreno J, Lopez-Bastida J, Worbes-Cerezo M, Serrano-Aguilar P. Health Related Quality of Life of Canary Islands citizens. BMC Public Health. 2010 Nov 5;10(1):675. PubMed Abstract
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Toyn JH, Lin XA, Thompson MW, Guss V, Meredith JE, Sankaranarayanan S, Barrezueta N, Corradi J, Majumdar A, Small DL, Hansard M, Lanthorn T, Westphal RS, Albright CF. Viable mouse gene ablations that robustly alter brain Abeta levels are rare. BMC Neurosci. 2010 Nov 5;11(1):143. PubMed Abstract
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McCampbell A, Wessner K, Marlatt MW, Wolffe C, Toolan D, Podtelezhnikov A, Yeh S, Zhang R, Szczerba P, Tanis KQ, Majercak J, Ray WJ, Savage M. Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine. J Neurochem. 2010 Nov 5; PubMed Abstract
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Chow KM, Guan H, Hersh LB. Aminopeptidases do not directly degrade tau protein. Mol Neurodegener. 2010 Nov 5;5(1):48. PubMed Abstract
separator
Hatipoglu MG, Kabay SC, Güven G. The clinical evaluation of the oral status in Alzheimer-type dementia patients. Gerodontology. 2010 Nov 5; PubMed Abstract
separator
Hidalgo C, Carrasco MA. Redox Control of Brain Calcium in Health and Disease. Antioxid Redox Signal. 2010 Nov 5; PubMed Abstract
separator
Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB, Huryn D. Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies. Curr Top Med Chem. 2010 Nov 4; PubMed Abstract
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Galanakis PA, Bazoti FN, Bergquist J, Markides K, Spyroulias GA, Tsarbopoulos A. Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by NMR spectroscopy. Biopolymers. 2010 Nov 4; PubMed Abstract
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Pascual B, Prieto E, Arbizu J, Marti-Climent J, Olier J, Masdeu JC. Brain Glucose Metabolism in Vascular White Matter Disease With Dementia. Differentiation From Alzheimer Disease. Stroke. 2010 Nov 4; PubMed Abstract
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Rahman A, Brew BJ, Guillemin GJ. Lead Dysregulates Serine/Threonine Protein Phosphatases in Human Neurons. Neurochem Res. 2010 Nov 4; PubMed Abstract

Beta Amyloid Peptides November 2010 Second Week Research Papers

Beta Amyloid Peptides November 2010 Second Week Research Papers

Michalke B, Nischwitz V. Review on metal speciation analysis in cerebrospinal fluid-current methods and results: A review. Anal Chim Acta. 2010 Dec 3;682(1-2):23-36. PubMed Abstract
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Saxena U. Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here? Expert Opin Ther Targets. 2010 Dec;14(12):1273-7. PubMed Abstract
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Cumming T, Brodtmann A. Dementia and stroke: the present and future epidemic. Int J Stroke. 2010 Dec;5(6):453-4. PubMed Abstract
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Hong XP, Peng CX, Wei W, Tian Q, Liu YH, Cao FY, Wang Q, Wang JZ. Relationship of Adult Neurogenesis with Tau Phosphorylation and GSK-3ß Activity in Subventricular Zone. Neurochem Res. 2010 Nov 9; PubMed Abstract
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Craik FI, Bialystok E, Freedman M. Delaying the onset of Alzheimer disease: Bilingualism as a form of cognitive reserve. Neurology. 2010 Nov 9;75(19):1726-9. PubMed Abstract
 
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Rodríguez-Rodríguez C, Rimola A, Alí-Torres J, Sodupe M, González-Duarte P. In silico strategies for the selection of chelating compounds with potential application in metal-promoted neurodegenerative diseases. J Comput Aided Mol Des. 2010 Nov 9; PubMed Abstract
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Takahashi RH, Tobiume M, Sato Y, Sata T, Gouras GK, Takahashi H. Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain. Neuropathology. 2010 Nov 9; PubMed Abstract
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Smith P, Al Hashimi A, Girard J, Delay C, Hébert SS. In vivo regulation of Amyloid precursor protein neuronal splicing by microRNAs. J Neurochem. 2010 Nov 9; PubMed Abstract
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Ludwig J, Höffle-Maas A, Samochocki M, Luttmann E, Albuquerque EX, Fels G, Maelicke A. Localization by site-directed mutagenesis of a galantamine binding site on a7 nicotinic acetylcholine receptor extracellular domain. J Recept Signal Transduct Res. 2010 Nov 9; PubMed Abstract
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Chen J, Armstrong AH, Koehler AN, Hecht MH. Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer's Aß Peptide and Reduce its Cytotoxicity. J Am Chem Soc. 2010 Nov 9; PubMed Abstract
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Sato Y, Nakamura T, Aoshima K, Oda Y. Quantitative and Wide-Ranging Profiling of Phospholipids in Human Plasma by Two-dimensional Liquid Chromatography/Mass Spectrometry. Anal Chem. 2010 Nov 9; PubMed Abstract
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García-Macia M, Vega-Naredo I, De Gonzalo-Calvo D, Rodríguez-González SM, Camello PJ, Camello-Almaraz C, Martín-Cano FE, Rodríguez-Colunga MJ, Pozo MJ, Coto-Montes AM. Melatonin induces neural SOD2 expression independent of the NF-kappaB pathway and improves the mitochondrial population and function in old mice. J Pineal Res. 2010 Nov 9; PubMed Abstract
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Nagaishi M, Yokoo H, Nakazato Y. Tau-positive glial cytoplasmic granules in multiple system atrophy. Neuropathology. 2010 Nov 9; PubMed Abstract
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Wu UI, Mai FD, Sheu JN, Chen LY, Liu YT, Huang HC, Chang HM. Melatonin inhibits microglial activation, reduces pro-inflammatory cytokine levels, and rescues hippocampal neurons of adult rats with acute Klebsiella pneumoniae meningitis. J Pineal Res. 2010 Nov 9; PubMed Abstract
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Brady OA, Meng P, Zheng Y, Mao Y, Hu F. Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1. J Neurochem. 2010 Nov 9; PubMed Abstract
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Robins Wahlin TB, Byrne GJ. Personality changes in Alzheimer's disease: a systematic review. Int J Geriatr Psychiatry. 2010 Nov 9; PubMed Abstract
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Fiala M, Chattopadhay M, La Cava A, Tse E, Liu G, Lourenco E, Eskin A, Liu PT, Magpantay L, Tse S, Mahanian M, Weitzman R, Tong J, Nguyen C, Cho T, Koo P, Sayre J, Martinez-Maza O, Rosenthal MJ, Wiedau-Pazos M. IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients. J Neuroinflammation. 2010 Nov 9;7(1):76. PubMed Abstract
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Frye CA, Paris JJ. Progesterone turnover to its 5alpha-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats. J Endocrinol Invest. 2010 Nov 8; PubMed Abstract
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Bilsland LG, Sahai E, Kelly G, Golding M, Greensmith L, Schiavo G. Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci U S A. 2010 Nov 8; PubMed Abstract
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Magill ST, Cambronne XA, Luikart BW, Lioy DT, Leighton BH, Westbrook GL, Mandel G, Goodman RH. microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A. 2010 Nov 8; PubMed Abstract
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Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O, Lassmann H, Turnbull DM, Mahad DJ. Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol. 2010 Nov 8; PubMed Abstract
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Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B. Replication of GWAS Associations for GAK and MAPT in Parkinson's Disease. Ann Hum Genet. 2010 Nov 8; PubMed Abstract
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Maheshwari M, Roberts JK, Desutter B, Duong K, Tingling JD, Fawver JN, Schall HE, Kahle M, Murray IV. Hydralazine prevents Aß fibril formation and modification by lipids in vitro. Biochemistry. 2010 Nov 8; PubMed Abstract
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Devi L, Alldred MJ, Ginsberg SD, Ohno M. Sex- and brain region-specific acceleration of beta-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease. Mol Brain. 2010 Nov 8;3(1):34. PubMed Abstract
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Lee JH, Cheng R, Barral S, Reitz C, Medrano M, Lantigua R, Jiménez-Velazquez IZ, Rogaeva E, St George-Hyslop PH, Mayeux R. Identification of Novel Loci for Alzheimer Disease and Replication of CLU, PICALM, and BIN1 in Caribbean Hispanic Individuals. Arch Neurol. 2010 Nov 8; PubMed Abstract

APP~Amyloid Precursor Protein

Amyloid Precursor Protein

Amyloid Precursor Protein


Synaptic Plasticity and the Mechanism of Alzheimer's Disease (Research and Perspectives in Alzheimer's Disease)


A biochemical hypothesis - that Alzheimer?s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.


Hardcover:  183 pages
Company: Springer  (2008-02-19)
ISBN: 3540763295
List Price: $149.00
Amazon Price: $97.36
Used Price: $94.37

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Intracellular Traffic and Neurodegenerative Disorders (Research and Perspectives in Alzheimer's Disease)

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.


Hardcover:  184 pages
Company: Springer  (2008-12-18)
ISBN: 3540879404
List Price: $159.00
Amazon Price: $69.74
Used Price: $69.73

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AMYLOID PRECURSOR PROTEIN

Author: Weiming Xia
Paperback: 
Company: NY  (1980)
List Price:
Amazon Price:

Alzheimer’s Research References/Papers: September 2009 4th Week’s: Alzheimer’s Research References/Papers

Alzheimer’s Research References/Papers: September 2009 4^th Week’s: Alzheimer’s Research References/Papers

Elsinghorst PW, Härtig W, Goldhammer S, Grosche J, Gütschow M. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques. Org Biomol Chem. 2009 Oct 7;7(19):3940-6.

Romero K, de Mars M, Frank D, Anthony M, Neville J, Kirby L, Smith K, Woosley RL. The Coalition Against Major Diseases: developing tools for an integrated drug development process for Alzheimer's and Parkinson's diseases. Clin Pharmacol Ther. 2009 Oct;86(4):365-7.

Harrison FE, Allard J, Bixler R, Usoh C, Li L, May JM, McDonald MP. Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutr Neurosci. 2009 Oct;12(5):203-18.

Lanctôt KL, Hsiung GY, Feldman HH, Masoud ST, Sham L, Herrmann N. Assessing the validity of deriving clinical dementia rating (CDR) global scores from independently-obtained functional rating scale (FRS) scores in vascular dementia with and without Alzheimer's disease. Int J Geriatr Psychiatry. 2009 Oct;24(10):1174-6.

Eidelberg D. Metabolic brain networks in neurodegenerative disorders: a functional imaging approach. Trends Neurosci. 2009 Oct;32(10):548-57.

Hedlund E, Perlmann T. Neuronal cell replacement in Parkinson's disease. J Intern Med. 2009 Oct;266(4):358-71.

Fusari A, Molina JA. [Sense of smell, physiological ageing and neurodegenerative diseases: II. Ageing and neurodegenerative diseases.] Rev Neurol. 2009 Oct 1-15;49(7):363-9.

Baquero M, Peset V, Burguera JA, Salazar-Cifre A, Bosca-Blasco ME, Del Olmo-Rodriguez A, Valero-Merino C, Munoz-Lacalle RA, En Nombre Del Nodo Enae Valencia EN. [Quality of life in Alzheimer's disease.] Rev Neurol. 2009 Oct 1-15;49(7):337-42.

Spuch C, Antequera D, Isabel Fernandez-Bachiller M, Isabel Rodríguez-Franco M, Carro E. A New Tacrine-Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer's Disease. Neurotox Res. 2009 Sep 23;

Kazanis I. The subependymal zone neurogenic niche: a beating heart in the centre of the brain: How plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed. Brain. 2009 Sep 22;

Zou K, Maeda T, Watanabe A, Liu J, Liu S, Oba R, Satoh YI, Komano H, Michikawa M. Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme. J Biol Chem. 2009 Sep 22;

Goodger ZV, Rajendran L, Trutzel A, Kohli BM, Nitsch RM, Konietzko U. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. J Cell Sci. 2009 Sep 22;

 

Buccafusco JJ. Emerging cognitive enhancing drugs. Expert Opin Emerg Drugs. 2009 Sep 22;

Boussert S, Diez-Perez I, Kogan MJ, de Oliveira E, Giralt E. An Intramolecular O-N Migration Reaction on Gold Surfaces: Toward the Preparation of Well-Defined Amyloid Surfaces. ACS Nano. 2009 Sep 22;

Sultana R, Banks WA, Butterfield DA. Decreased levels of PSD95 and two associated proteins and increased levels of BCl(2) and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease. J Neurosci Res. 2009 Sep 22;

Latourelle JC, Pankratz N, Dumitriu A, Wilk JB, Goldwurm S, Pezzoli G, Mariani CB, DeStefano AL, Halter C, Gusella JF, Nichols WC, Myers RH, Foroud T, Coordinators PP, Laboratory PP, Coordinators GI, Laboratories GM. Genomewide Association Study for Onset Age in Parkinson Disease. BMC Med Genet. 2009 Sep 22;10(1):98.

Henneman WJ, Vrenken H, Barnes J, Sluimer IC, Verwey NA, Blankenstein MA, Klein M, Fox NC, Scheltens P, Barkhof F, van der Flier WM. Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. Neurology. 2009 Sep 22;73(12):935-40.

Triebel KL, Martin R, Griffith HR, Marceaux J, Okonkwo OC, Harrell L, Clark D, Brockington J, Bartolucci A, Marson DC. Declining financial capacity in mild cognitive impairment: A 1-year longitudinal study. Neurology. 2009 Sep 22;73(12):928-34.

Ye J, Meng X, Yan C, Wang C. Effect of Purple Sweet Potato Anthocyanins on beta-Amyloid-Mediated PC-12 Cells Death by Inhibition of Oxidative Stress. Neurochem Res. 2009 Sep 22;

Mandal M, Yan Z. PIP2 Regulation of NMDA Receptor Channels in Cortical Neurons. Mol Pharmacol. 2009 Sep 21;

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